基因名：
USP16
产品别名：
UBP-M； UBPM； USP16； ubiquitin specific peptidase 16； ubiquitin specific peptidase 16； ubiquitin carboxyl-terminal hydrolase 16； deubiquitinating enzyme 16； ubiquitin specific protease 16； ubiquitin thioesterase 16； ubiquitin thiolesterase 16； ubiquitin-processing protease UBP-M； ubiquitin-specific processing protease 16； 去泛素酶16；
背景信息：
USP16 is an active deubiquitinating enzyme (DUB) encoded on chromosome 21, trisomy of which causes Down’s syndrome (DS). USP16 is a phosphoprotein, phosphorylation of USP16 controls its cellular localization, but no effect on its DUB activity. USP16 deubiquitinates histone 2A (H2A), through which USP16 might regulate gene expression and cell cycle progression. Increased USP16 protein levels in people with DS might contribute to the development of certain phenotypes of DS.
