基因名：
MYL12A
产品别名：
HEL-S-24； MLC-2B； MLCB； MRCL3； MRLC3； MYL2B； MYL12A； myosin light chain 12A； myosin light chain 12A； myosin regulatory light chain 12A； epididymis secretory protein Li 24； myosin RLC； myosin regulatory light chain 2, nonsarcomeric； myosin regulatory light chain 3； myosin regulatory light chain MRLC3； myosin, light chain 12A, regulatory, non-sarcomeric； myosin, light polypeptide, regulatory, non-sarcomeric (20kD)； 磷酸化肌球蛋白调节轻链MRLC3； 肌球蛋白轻链12A(MYL12A)；
背景信息：
Myosin is a highly conserved, ubiquitously expressed protein that interacts with Actin to generate the force for cellular movements. Conventional myosins are hexameric proteins consisting of two heavy chain subunits, a pair of non-phosphorylatable light chain subunits and a pair of phosphorylatable light chain subunits. Three general classes of myosin have been cloned: smooth muscle myosins, striated muscle myosins and non-muscle myosins. Myosin regulatory light chains, including MRCL3 (also known as MRLC3 or MLCB), MRLC2 (also known as MLC-B) and MYL9 (also known as LC20, MLC2, MRLC1 or MYRL2), regulate contraction in smooth muscle and non-muscle cells via phosphorylation by myosin light chain kinase (MLCK). Phosphorylation of myosin regulatory light chains, catalyzed by MLCK in the presence of calcium and calmodulin, increases the Actin-activated myosin ATPase activity, thereby regulating the contractile activity. Myosin light chain is also located in striated skeletal muscle, where its function remains undefined.
