基因名：
IGF2BP2
产品别名：
IMP-2； IMP2； VICKZ2； IGF2BP2； insulin like growth factor 2 mRNA binding protein 2； insulin like growth factor 2 mRNA binding protein 2； insulin-like growth factor 2 mRNA-binding protein 2； IGF-II mRNA-binding protein 2； IGF2 mRNA-binding protein 2； VICKZ family member 2； 胰岛素样生长因子2-mRNA结合蛋白2(IGF2BP2)； 胰岛素样生长因子ⅡmRNA结合蛋白2；
背景信息：
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to the 5'-UTR of the Insulin-Like Growth Factor 2 (IGF2) mRNA. This binding is isoform-specific. IGF2BP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replication analyses.
