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重组转录因子同源框蛋白SIX2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

Recombinant SIX2
Recombinant SIX homeobox 2 protein
基因名:

SIX2


产品别名:

SIX2; SIX homeobox 2; SIX homeobox 2; homeobox protein SIX2; sine oculis homeobox homolog 2; 转录因子同源框蛋白SIX2;


背景信息:
The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Six4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint. Six2 is highly expressed in fetal tissues but expression is limited in adult tissues.
 
 
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