基因名：
GIPC1
产品别名：
C19orf3； GIPC； GLUT1CBP； Hs.6454； IIP-1； NIP； OPDM2； RGS19IP1； SEMCAP； SYNECTIIN； SYNECTIN； TIP-2； GIPC1； GIPC PDZ domain containing family member 1； GIPC PDZ domain containing family member 1； PDZ domain-containing protein GIPC1； GAIP C-terminus-interacting protein； GLUT1 C-terminal binding protein； IGF-1 receptor interacting protein 1； RGS-GAIP-interacting protein； RGS19-interacting protein 1； regulator of G-protein signalling 19 interacting protein 1； tax interaction protein 2； 胰岛素样生长因子1受体1；
背景信息：
GIPC, for GAIP interacting protein at the C terminus (also designated SEMCAP-1 or synectin), is a PDZ domain containing protein that interacts with RGS-GAIP, a GTPase-activating protein (GAP) for G(a i) subunits. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. PDZ domain-containing proteins are primarily localized to cell-cell junctions in epithelial cells and neurons where they coordinate the assembly of multiprotein complexes. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrin-coated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.
