基因名：
SRSF10
产品别名：
FUSIP1； FUSIP2； NSSR； PPP1R149； SFRS13； SFRS13A； SRp38； SRrp40； TASR； TASR1； TASR2； SRSF10； serine and arginine rich splicing factor 10； serine and arginine rich splicing factor 10； serine/arginine-rich splicing factor 10； 40 kDa SR-repressor protein； FUS interacting protein (serine-arginine rich) 1； FUS-interacting protein (serine-arginine rich) 2； SR splicing factor 10； TLS-associated SR protein； TLS-associated protein TASR； TLS-associated protein with SR repeats； TLS-associated protein with Ser-Arg repeats； TLS-associated serine-arginine protein 1； TLS-associated serine-arginine protein 2； neural-salient SR protein； protein phosphatase 1, regulatory subunit 149； serine-arginine repressor protein (40 kDa)； splicing factor SRp38； splicing factor, arginine/serine-rich 13； splicing factor, arginine/serine-rich 13A； 富含丝氨酸/精氨酸重复结构蛋白；
背景信息：
FUSIP1 is a member of the Serine/Arginine (SR) family of splicing factors. Members of the SR family all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. SR factors are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. Expressed in a variety of tissues with low expression in kidney, liver and heart, FUSIP1 localizes to the cytoplasm and nuclear speckles. In its dephosphorylated form (occurring during M phase of the cell cycle), FUSIP1 functions as a potent general repressor of pre-mRNA splicing and can interact with U1 SnRNP 70. In its phosphorylated form, FUSIP1 interacts with Tra-2∫ and, together, they may cooperate in the regulation of splicing. Four isoforms exist for FUSIP1. In neurons, FUSIP1 isoforms may act to either positively or negatively regulate alternative splicing.
