基因名：
SUB1
产品别名：
P15； PC4； p14； SUB1； SUB1 regulator of transcription； SUB1 regulator of transcription； activated RNA polymerase II transcriptional coactivator p15； SUB1 homolog, transcriptional regulator； activated RNA polymerase II transcription cofactor 4； positive cofactor 4； 正辅因子4；
背景信息：
SUB1 belongs to the transcriptional coactivator PC4 family. It is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. SUB1 binds single-stranded DNA. Single-stranded DNA-binding proteins play many roles in nucleic acid metabolism, but their importance during transcription remains unclear. SUB1 exhibits strong genetic interactions with factors necessary for promoter melting. It localizes near the transcription bubble in vitro and binds to promoters in vivo dependent upon preinitiation complexes assembly. SUB1 interacts with the nontemplate strand of RNApII complexes during initiation. It may also be involved in stabilizing the multiprotein transcription complex.
