基因名：
CLP1
产品别名：
HEAB； hClp1； CLP1； cleavage factor polyribonucleotide kinase subunit 1； cleavage factor polyribonucleotide kinase subunit 1； polyribonucleotide 5'-hydroxyl-kinase Clp1； ATP/GTP-binding protein； cleavage and polyadenylation factor I subunit 1； homolog of yeast CFIA subunit Clp1p； polyadenylation factor Clp1； polynucleotide kinase Clp1； pre-mRNA cleavage complex II protein Clp1； 多聚腺苷酸因子Clp1蛋白；
背景信息：
HEAB is a 425 amino acid nuclear protein that belongs to the Clp1 family. Utilizing magnesium, manganese or nickel as cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D; mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB exists as two isoforms due to alternative splicing events.
