基因名：
TMED1
产品别名：
IL1RL1LG； Il1rl1l； Tp24； p24g1； TMED1； transmembrane p24 trafficking protein 1； transmembrane p24 trafficking protein 1； transmembrane emp24 domain-containing protein 1； IL1RL1-binding protein； interleukin 1 receptor-like 1 ligand； p24 family protein gamma-1； putative T1/ST2 receptor-binding protein； transmembrane emp24 protein transport domain containing 1；
背景信息：
TMED1 (Transmembrane Emp24 domain-containing protein 1) is a member of the TMED family of proteins (gene name TMED1). The TMED family of proteins are localized to membranes of the early secretory pathway, including the endoplasmic reticulum and Golgi, and function in vesicular protein trafficking. TMED1 is a 59 kDa monomer and has been reported to exist as homodimer. It contains 1 GOLD domain and is widely expressed. TMED1 is important in regulating innate immune signaling through its interaction with ST2L. Specifically, the GOLD domain in TMED1 interacts with the TIR domain of ST2L, a receptor for IL 33. This interaction promotes ST2L association with IL-33, allowing downstream signaling cascade activating MAP kinases, p38, and JNK. Studies have shown knockdown of TMED-1 in HUVECs impairs the IL-33 induced response resulting in reduction of IL-6 and IL-8 productions.
标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
