基因名:
RIPK3
产品别名:
RIP3; RIPK3; receptor interacting serine/threonine kinase 3; receptor interacting serine/threonine kinase 3; receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; receptor interacting protein 3; 受体相互作用丝氨酸苏氨酸激酶3(RIPK3); 受体结合丝氨酸苏氨酸激酶3;
背景信息:
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]