基因名：
WWP1
产品别名：
AIP5； Tiul1； hSDRP1； WWP1； WW domain containing E3 ubiquitin protein ligase 1； WW domain containing E3 ubiquitin protein ligase 1； NEDD4-like E3 ubiquitin-protein ligase WWP1； HECT-type E3 ubiquitin transferase WWP1； Nedd-4-like ubiquitin-protein ligase； TGIF-interacting ubiquitin ligase 1； WW domain-containing protein 1； atrophin-1 interacting protein 5； WW结构域E3泛素连接酶1；
背景信息：
WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.
