基因名：
UBE2C
产品别名：
UBCH10； dJ447F3.2； UBE2C； ubiquitin conjugating enzyme E2 C； ubiquitin conjugating enzyme E2 C； ubiquitin-conjugating enzyme E2 C； (E3-independent) E2 ubiquitin-conjugating enzyme C； E2 ubiquitin-conjugating enzyme C； cyclin-selective ubiquitin carrier protein； mitotic-specific ubiquitin-conjugating enzyme； ubiquitin conjugating enzyme E2C； ubiquitin-protein ligase C； 泛素结合酶E2C(UBE2C)； 泛素蛋白连接酶C；
背景信息：
Ubiquitin-Conjugating Enzyme E2 C (UBE2C) is a 179 amino acid enzyme that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2C is highly expressed in tumor tissues and at low levels in most adult normal tissues. UBE2C is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C accepts Ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), which has E3 ubiquitin ligase activity, and targets for destruction substrates from the preceding mitosis (Cyclin A, Cyclin B, Securin, Geminin).
