基因名：
TPPP
产品别名：
TPPP/p25； TPPP1； p24； p25； p25alpha； TPPP； tubulin polymerization promoting protein； tubulin polymerization promoting protein； tubulin polymerization-promoting protein； 25 kDa brain-specific protein； brain specific protein p25 alpha； glycogen synthase kinase 3 (GSK3) inhibitor p24； p25-alpha； 促微管蛋白聚合蛋白(TPPP)； 促微管蛋白聚合蛋白(TPPP)真核蛋白； 微管蛋白聚合促进蛋白24；
背景信息：
Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome.
