基因名：
BAZ1A
产品别名：
ACF1； WALp1； WCRF180； hACF1； BAZ1A； bromodomain adjacent to zinc finger domain 1A； bromodomain adjacent to zinc finger domain 1A； bromodomain adjacent to zinc finger domain protein 1A； ATP-dependent chromatin remodeling protein； ATP-utilizing chromatin assembly and remodeling factor 1； CHRAC subunit ACF1； hWALp1； williams syndrome transcription factor-related chromatin-remodeling factor 180； 溴区结构域相邻锌指蛋白1A；
背景信息：
Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Component of the histone-fold protein complex CHRAC complex which faciliates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.
