基因名：
RNF139
产品别名：
HRCA1； RCA1； TRC8； RNF139； ring finger protein 139； ring finger protein 139； E3 ubiquitin-protein ligase RNF139； RING-type E3 ubiquitin transferase RNF139； multiple membrane spanning receptor TRC8； patched related protein translocated in renal cancer； translocation in renal carcinoma on chromosome 8 protein； translocation in renal carcinoma, chromosome 8； 环指蛋白139；
背景信息：
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
