基因名：
CD300A
产品别名：
CLM-8； CMRF-35-H9； CMRF-35H； CMRF35-H； CMRF35-H9； CMRF35H； CMRF35H9； IGSF12； IRC1； IRC1/IRC2； IRC2； IRp60； CD300A； CD300a molecule； CD300a molecule； CMRF35-like molecule 8； CD300 antigen-like family member A； CD300a antigen； CMRF35H leukocyte immunoglobulin-like receptor； NK inhibitory receptor； immunoglobulin superfamily member 12； inhibitory receptor protein 60； leukocyte membrane antigen； 免疫球蛋白超家族成员12； 免疫球蛋白超家族成员12(IGSF12)；
背景信息：
CD300A is a single-pass type I membrane protein that belongs to the CD300 family. CD300A consists of a 163 amino acid (aa) extracellular domain (ECD) with one Ig-like V- type domain, a 21 amino acid transmembrane segment, and a 98 amino acid cytoplasmic domain with tyrosine residues. CD300A is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. CD300A is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.
