基因名:
CBX3
产品别名:
HECH; HP1-GAMMA; HP1Hs-gamma; CBX3; chromobox 3; chromobox 3; chromobox protein homolog 3; HP1 gamma homolog; chromobox homolog 3 (HP1 gamma homolog, Drosophila); heterochromatin protein 1 homolog gamma; heterochromatin protein HP1 gamma; heterochromatin-like protein 1; modifier 2 protein; 异染色质蛋白1-γ/HP-1γ; 染色框同源物3(CBX3); 磷酸化染色质相关蛋白1-γ;
背景信息:
HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.