基因名:
Neurog2
产品别名:
Atoh4; Math4A; bHLHa8; ngn-2; ngn2; Neurog2; neurogenin 2; neurogenin 2; neurogenin-2; atonal homolog 4; helix-loop-helix protein mATH-4A; protein atonal homolog 4; 神经元素2;
背景信息:
Neurogenin 2 is a helix-loop-helix class of transcription factor. Transcription factors with bHLH motifs modulate critical events in the development of the mammalian neocortex. The transition from proliferation to neurogenesis involves a coordinate increase in the activity of proneural bHLH factors, including Neurogenin 2 and a decrease in the activity of Hes and Id factors. bHLH factors have key roles in corticogenesis, affecting the timing of differentiation and the specification of cell fate.