重组Apollon凋亡抑制蛋白

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重组Apollon凋亡抑制蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

重组含杆状病毒IAP重复蛋白6(BIRC6)
Recombinant Birc6

基因名：

Birc6

产品别名：

A430032G04Rik； A430040A19Rik； AA501170； Bruce； D630005A10Rik； mKIAA1289； Birc6； baculoviral IAP repeat-containing 6； baculoviral IAP repeat-containing 6； baculoviral IAP repeat-containing protein 6； BIR repeat-containing ubiquitin-conjugating enzyme； RING-type E3 ubiquitin transferase BIRC6； apollon； baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme； baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6； ubiquitin-conjugating BIR domain enzyme apollon； Apollon凋亡抑制蛋白；含杆状病毒IAP重复蛋白6(BIRC6)；

背景信息：

Conserved genes that encode inhibitors of apoptosis proteins (IAPs) are frequently overexpressed in human cancers and are associated with resistance to therapy. IAPs contain a 70 amino acid cysteine and histidine rich baculovirus IAP repeat (BIR) and often a zinc binding RING finger. Chen et al. (1999) found that some brain cancer cell lines with high expression of BIRC6 exhibited resistance to apoptosis in the presence of anticancer drugs. Treatment of a high expressing cell line with BIRC6 antisense oligonucleotides reduced BIRC6 expression and reversed the resistance to anticancer drugs.