基因名：
Cbx5
产品别名：
2610029O15Rik； C75991； HP1； Hp1a； Hp1alpha； Cbx5； chromobox 5； chromobox 5； chromobox protein homolog 5； HP1 alpha； chromobox homolog 5； heterochromatin protein 1 alpha； heterochromatin protein 1 homolog alpha； mHP1(alpha)； 异染色质蛋白1-α； 磷酸化CBX5； 磷酸化异染色质蛋白1；
背景信息：
HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane.
HP1 proteins are relatively small proteins (25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.
