基因名：
Twist2
产品别名：
Dermo1； bHLHa39； Twist2； twist basic helix-loop-helix transcription factor 2； twist basic helix-loop-helix transcription factor 2； twist-related protein 2； dermis-expressed protein 1； twist homolog 2； TWIST蛋白2；
背景信息：
Twist2 (Twist homolog 2) is a basic helix-loop-helix (bHLH) transcription factor which acts as a transcriptional repressor. It binds to the E-box consensus sequence 5'-CANNTG-3' and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Efficient DNA binding requires dimerization with another bHLH protein. Twist2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis.
