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重组FC段γ受体3/免疫球蛋白GFc段受体III
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

Recombinant Fcgr3
Recombinant Fc receptor, IgG, low affinity III protein
基因名:

Fcgr3


产品别名:

CD16; Fcgr3; Fc receptor, IgG, low affinity III; Fc receptor, IgG, low affinity III; low affinity immunoglobulin gamma Fc region receptor III; Fc gamma receptor III; Fcg receptor III; FcgammaRIII; fc-gamma RIII; fcRIII; igG Fc receptor III; FC段γ受体3/免疫球蛋白GFc段受体III;


背景信息:
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
 
 
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