基因名：
Fkbp8
产品别名：
38kDa； FKBP-38； FKBP-8； FKBPR38； Fkbp38； mFKBP38； Fkbp8； FK506 binding protein 8； FK506 binding protein 8； peptidyl-prolyl cis-trans isomerase FKBP8； 38 kDa FK506-binding protein； 38 kDa FKBP； FK506-binding protein 38； PPIase FKBP8； rotamase； FK506结合蛋白38； FK506结合蛋白8(FKBP8)； 肽基脯氨酸异构酶酶FKBP8；
背景信息：
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
Tissue specificity: Widely expressed. Highest levels seen in the brain.
