基因名:
Foxd3
产品别名:
CWH3; Genesis; Hfh2; Foxd3; forkhead box D3; forkhead box D3; forkhead box protein D3; HFH-2; HNF-3/forkhead homolog 2; HNF3/FH transcription factor genesis; hepatocyte nuclear factor 3 forkhead homolog 2; 叉头框蛋白D3(FOXD3); 叉头蛋白D3;
背景信息:
Embryonic stem cells require the forkhead transcriptional regulator FoxD3 for survival. Following gastrulation, FoxD3 generally gets downregulated, except in the neural crest. A variety of growth factors induce FoxD3 expression, including FGF8 and SNAIL, maintaining the effected cells in an undifferentiated state. Thus defects in FoxD3 induction may cause premature differentiation and/or migration-asociated birth defects.