基因名：
Lat
产品别名：
p36-38； pp36； Lat； linker for activation of T cells； linker for activation of T cells； linker for activation of T-cells family member 1； 36 kDa phospho-tyrosine adapter protein； linker protein； T-细胞激活连接蛋白(LAT)； T细胞活化连接蛋白； 磷酸化T细胞活化连接蛋白；
背景信息：
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
