基因名：
Blnk
产品别名：
BASH； Bca； Ly-57； Ly57； Lyw-57； SLP-65； Blnk； B cell linker； B cell linker； B-cell linker protein； B-cell adapter containing a SH2 domain protein； B-cell adapter containing a Src homology 2 domain protein； cytoplasmic adapter protein； lymphocyte antigen 57； src homology 2 domain-containing leukocyte protein of 65 kDa； B-细胞连接蛋白(BLNK)； B淋巴细胞连接蛋白； 磷酸化T淋巴细胞连接蛋白；
背景信息：
B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.
