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重组B-细胞连接蛋白(BLNK)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

重组B淋巴细胞连接蛋白
Recombinant Blnk
基因名:

Blnk


产品别名:

BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65; Blnk; B cell linker; B cell linker; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; cytoplasmic adapter protein; lymphocyte antigen 57; src homology 2 domain-containing leukocyte protein of 65 kDa; B-细胞连接蛋白(BLNK); B淋巴细胞连接蛋白; 磷酸化T淋巴细胞连接蛋白;


背景信息:
B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

 
 
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