基因名：
Mgrn1
产品别名：
2610042J20Rik； mKIAA0544； md； nc； Mgrn1； mahogunin, ring finger 1； mahogunin, ring finger 1； E3 ubiquitin-protein ligase MGRN1； RING-type E3 ubiquitin transferase MGRN1； mahoganoid； mahogunin RING finger protein 1； probable E3 ubiquitin-protein ligase MGRN1； 环指蛋白156；
背景信息：
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
