基因名：
Kitl
产品别名：
Clo； Con； Gb； Kitlg； Mgf； SCF； SF； SLF； Sl； blz； contrasted； Kitl； kit ligand； kit ligand； kit ligand； C-kit ligand； Steel factor； cloud gray； grizzle-belly； hematopoietic growth factor KL； mast cell growth factor； stem cell factor；
背景信息：
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.
