基因名：
Commd1
产品别名：
AI256843； Murr1； U2/Mu； Commd1； COMM domain containing 1； COMM domain containing 1； COMM domain-containing protein 1； U2af1-rs1 region 1； copper metabolism domain containing 1； protein Murr1； 铜代谢结构域蛋白1；
背景信息：
Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.
Tissue specificity: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.
