基因名:
Nlk
产品别名:
AI194375; Nlk; nemo like kinase; nemo like kinase; serine/threonine-protein kinase NLK; Nemo样激酶; 磷酸化Nemo样激酶;
背景信息:
Nemo-like kinase (NLK) plays a role in cell fate determination and is required for differentiation of bone marrow stromal cells. It acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. It may suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. (referenced from swissprot)