基因名：
Ptpn22
产品别名：
70zpep； PEP； Ptpn8； Ptpn22； protein tyrosine phosphatase, non-receptor type 22 (lymphoid)； protein tyrosine phosphatase, non-receptor type 22 (lymphoid)； tyrosine-protein phosphatase non-receptor type 22； PEST domain-enriched tyrosine phosphatase； hematopoietic cell protein-tyrosine phosphatase 70Z-PEP； protein tyrosine phosphatase, non-receptor type 8； 蛋白酪氨酸磷酸酶非受体型22； 非受体型蛋白酪氨酸磷酸酶22(PTPN22)；
背景信息：
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
