基因名:
Sirpa
产品别名:
AI835480; Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1; SHPS-1; SIRP; Sirpa; signal-regulatory protein alpha; signal-regulatory protein alpha; tyrosine-protein phosphatase non-receptor type substrate 1; CD172 antigen-like family member A; SHP substrate 1; brain Ig-like molecule with tyrosine-based activation motifs; brain immunological-like with tyrosine-based motifs; inhibitory receptor SHPS-1; mSIRP-alpha1; myD-1 antigen; protein tyrosine phosphatase, non-receptor type substrate 1; signal-regulatory protein alpha-1; sirp-alpha-1; 信号调节蛋白α; 信号调节蛋白α(SIRPa);
背景信息:
Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation