基因名：
Rlim
产品别名：
AL022832； AW743871； Ha1r； Rlim1； Rnf12； Rlim； ring finger protein, LIM domain interacting； ring finger protein, LIM domain interacting； E3 ubiquitin-protein ligase RLIM； Hoxa1 regulated； LIM domain-interacting RING finger protein； RING finger LIM domain-binding protein； RING-type E3 ubiquitin transferase RLIM； ring finger protein 12； 环指蛋白12；
背景信息：
RLIM, also known as RNF12 (RING finger protein 12) or NY-REN-43, is a 624 amino acid RING-H2 zinc finger protein that is involved in protein ubiquitinylation and subsequent degradation. Expressed in a variety of tissues, RLIM binds to the LIM domain of various proteins and functions as a protein ligase that negatively co-regulates LIM homeodomain (LIM-HD) transcription factors. Through its interaction with Sin3A, a component of the histone deacetylase corepressor complex, RLIM is able to recruit the corepressor complex to LIM-HD proteins, thereby inhibiting LIM-HD transcription. In addition to recruiting the deacetylase complex to LIM-HD proteins, RLIM is able to bind to, ubiquinate and subsequently degrade CLIM proteins, which function as positive co-regulators of LIM-HD transcription factors. RLIM contains one RING-type zinc finger and is implicated in renal cell carcinoma.
