基因名：
CASC3
产品别名：
BTZ； MLN51； CASC3； CASC3 exon junction complex subunit； CASC3 exon junction complex subunit； protein CASC3； MLN 51； barentsz； cancer susceptibility 3； cancer susceptibility candidate 3； cancer susceptibility candidate gene 3 protein； metastatic lymph node 51； metastatic lymph node gene 51 protein； protein barentsz； 磷酸化肿瘤易感候选基因3； 肿瘤易感候选基因3；
背景信息：
The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exon–exon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex serves as a key modulator of spliced mRNA metabolism. MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. The function of MLN51 in mammals remains elusive. Its fly homolog, named barentsz, as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte. Magoh and Y14, the human homologs of mago nashi and tsunagi, are core components of the exon junction complex (EJC). The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, nonsense-mediated mRNA decay, and translation. Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes.
