基因名：
FAN1
产品别名：
KIAA1018； KMIN； MTMR15； hFAN1； FAN1； FANCD2 and FANCI associated nuclease 1； FANCD2 and FANCI associated nuclease 1； fanconi-associated nuclease 1； FANCD2/FANCI-associated nuclease 1； coiled-coil domain-containing protein MTMR15； fanconi anemia associated nuclease 1； myotubularin-related protein 15； 范可尼综合征相关蛋白FAN1；
背景信息：
Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.
