基因名：
KDM2A
产品别名：
CXXC8； FBL11； FBL7； FBXL11； JHDM1A； LILINA； KDM2A； lysine demethylase 2A； lysine demethylase 2A； lysine-specific demethylase 2A； CXXC-type zinc finger protein 8； F-box and leucine-rich repeat protein 11； F-box/LRR-repeat protein 11； [Histone-H3]-lysine-36 demethylase 1A； jmjC domain-containing histone demethylation protein 1A； jumonji C domain-containing histone demethylase 1A； lysine (K)-specific demethylase 2A； FBXL11蛋白；
背景信息：
F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and protein recruitment. F-box proteins are members of a large family that regulate the cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, for degradation by the proteasome after ubiquitination. FBL11, also known as FBXL11 (F-box and leucine-rich repeat protein 11), CXXC8, KDM2A, JHDM1A (JmjC domain-containing histone demethylation protein 1A) or LILINA, is a 1,162 amino acid member of the F-box protein family that contains one F-box domain and localizes to the nucleus. Expressed ubiquitously with highest expression in testis, ovary and brain, FBL11 functions to demethylate the Lys-36 residue of histone H3, thereby modulating the histone code. Additionally, FBL11 is thought to promote the ubiquitination and subsequent degradation of various phosphorylated proteins. Three isoforms of FBL11 exist due to alternative splicing events.
