基因名:
WDFY3
产品别名:
ALFY; BCHS; MCPH18; ZFYVE25; WDFY3; WD repeat and FYVE domain containing 3; WD repeat and FYVE domain containing 3; WD repeat and FYVE domain-containing protein 3; autophagy-linked FYVE protein; WDFY3蛋白;
背景信息:
WDFY3 was identified in a screen for phosphatidylinositol 3 phosphate binding proteins. The FYVE domain is a zinc binding domain found in many PtdIns binding proteins and is proposed to target proteins to membrane lipids. WDFY3 has been shown localized to the nuclear membrane and within autophagic membranes and it is proposed to function as a link between protein aggregates and the autophagic machinery. WDFY3 is also known as autophagy linked FYVE protein.