基因名：
WAPL
产品别名：
FOE； KIAA0261； WAPAL； WAPL； WAPL cohesin release factor； WAPL cohesin release factor； wings apart-like protein homolog； friend of EBNA2 (Epstein-Barr virus nuclear protein 2)； friend of EBNA2 protein； EBV核蛋白2/EBNA2；
背景信息：
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
