基因名：
ARHGAP26
产品别名：
GRAF； GRAF1； OPHN1L； OPHN1L1； ARHGAP26； Rho GTPase activating protein 26； Rho GTPase activating protein 26； rho GTPase-activating protein 26； GTPase regulator associated with focal adhesion kinase pp125(FAK)； oligophrenin-1-like protein； Rho GTP酶激活蛋白26；
背景信息：
Cellular signaling by G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydroylsis. The GTPase regulator associated with focal adhesion kinase (GRAF) has GAP activity toward Rho A and Cdc42, but not Rac1. GRAF is ubiquitously expressed with high levels in heart and brain. Expression of GRAF causes clearing of stress fibers and formation of long actin based filopodial-like extensions. Fusion of MLL with GRAF, MLL/GRAF, is included in a rare genetic subgroup of acute myeloid leukemia (AML) cases.
