基因名：
SARM1
产品别名：
HsTIR； MyD88-5； SAMD2； SARM； hSARM1； SARM1； sterile alpha and TIR motif containing 1； sterile alpha and TIR motif containing 1； NAD(+) hydrolase SARM1； NADP(+) hydrolase SARM1； NADase SARM1； SAM domain-containing protein 2； sterile alpha and Armadillo repeat protein； sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila； sterile alpha and TIR motif-containing protein 1； sterile alpha motif domain-containing protein 2； tir-1 homolog； SARM蛋白；
背景信息：
SARM, also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1 and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate immune responses and may also play a role in the negative regulation of NFⅹB activation. SARM exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 17.
