基因名：
CLASP2
产品别名：
CLASP2； cytoplasmic linker associated protein 2； cytoplasmic linker associated protein 2； CLIP-associating protein 2； CLIP-associating protein CLASP2； multiple asters (Mast)-like homolog 2； protein Orbit homolog 2； 细胞连接相关蛋白2；
背景信息：
CLASP2 is a microtubule plus end tracking protein that promotes the stabilization of dynamic microtubules and is required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. CLASP2 may act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3 kinase signaling. CLASP2 also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
