基因名：
PHF8
产品别名：
JHDM1F； KDM7B； MRXSSD； ZNF422； PHF8； PHD finger protein 8； PHD finger protein 8； histone lysine demethylase PHF8； [histone H3]-dimethyl-L-lysine(36) demethylase PHF8； [histone H3]-dimethyl-L-lysine(9) demethylase PHF8； jumonji C domain-containing histone demethylase 1F； PHD指蛋白8(PHF8)； 组蛋白赖氨酸去甲基化酶PHF8；
背景信息：
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
