基因名：
ARHGEF12
产品别名：
LARG； PRO2792； ARHGEF12； Rho guanine nucleotide exchange factor 12； Rho guanine nucleotide exchange factor 12； rho guanine nucleotide exchange factor 12； KMT2A/ARHGEF12 fusion protein； Rho guanine nucleotide exchange factor (GEF) 12； leukemia-associated RhoGEF； leukemia-associated rho guanine nucleotide exchange factor； Rho的鸟嘌呤核苷酸交换因子12；
背景信息：
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia (from EntrezGene). LARG has also been implicated in linking heterotrimeric G proteins to microtubule organisation in regulation of cell polarity.
