基因名：
RRP8
产品别名：
KIAA0409； NML； RRP8； ribosomal RNA processing 8； ribosomal RNA processing 8； ribosomal RNA-processing protein 8； RRP8 methyltransferase homolog； cerebral protein 1； nucleomethylin； ribosomal RNA processing 8, methyltransferase, homolog； 脑蛋白1；
背景信息：
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
