基因名：
SIRT1
产品别名：
SIR2； SIR2L1； SIR2alpha； SIRT1； sirtuin 1； sirtuin 1； NAD-dependent protein deacetylase sirtuin-1； NAD-dependent protein deacylase sirtuin-1； SIR2-like protein 1； regulatory protein SIR2 homolog 1； sirtuin type 1； 沉默调节蛋白1； 沉默调节蛋白1(SIRT1)； 磷酸化沉默调节蛋白1；
背景信息：
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
