基因名：
SUZ12
产品别名：
CHET9； IMMAS； JJAZ1； SUZ12； SUZ12 polycomb repressive complex 2 subunit； SUZ12 polycomb repressive complex 2 subunit； polycomb protein SUZ12； chET 9 protein； chromatin precipitated E2F target 9 protein； joined to JAZF1 protein； suppressor of zeste 12 protein homolog； Zeste 12同源物1抑制因子2(SUZ12)； 胚胎干细胞抑制蛋白Suz12；
背景信息：
UZ12 is a polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. SUZ12 is a component of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3.
SUZ12 is a component of the PRC2 complex, composed of EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like BMI1, CBX4, CBX8, PHC2, PHC3, SCMH1, RING1 and RNF2. SUZ12 mRNA is upregulated in a number of tumors including breast and colon.
