基因名:
SCRIB
产品别名:
CRIB1; SCRB1; SCRIB1; Vartul; oSCRIB; SCRIB; scribble planar cell polarity protein; scribble planar cell polarity protein; protein scribble homolog; scribbled homolog; scribbled planar cell polarity protein; SCRIBBLE蛋白;
背景信息:
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]