基因名：
DDAH1
产品别名：
DDAH； DDAH-1； DDAHI； HEL-S-16； DDAH1； dimethylarginine dimethylaminohydrolase 1； dimethylarginine dimethylaminohydrolase 1； N(G),N(G)-dimethylarginine dimethylaminohydrolase 1； NG, NG-dimethylarginine dimethylaminohydrolase； dimethylargininase-1； epididymis secretory protein Li 16； 二甲基精氨酸二甲胺水解酶1(DDAH1)； 双甲基精氨酸水解酶1；
背景信息：
DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production (1,2). Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation (3). DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA) (4). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues (1).
