基因名：
MKRN1
产品别名：
RNF61； MKRN1； makorin ring finger protein 1； makorin ring finger protein 1； E3 ubiquitin-protein ligase makorin-1； RING finger protein 61； RING-type E3 ubiquitin transferase makorin-1； 环指蛋白61；
背景信息：
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
