基因名：
Grem1
产品别名：
Cktsf1b1； Drm； Grem； ld； Grem1； gremlin 1, DAN family BMP antagonist； gremlin 1, DAN family BMP antagonist； gremlin-1； cysteine knot superfamily 1, BMP antagonist 1； down-regulated in Mos-transformed cells protein； down-regulated in v-mos-transformed cells； Gremlin 1蛋白(GREM1)； 骨形态形成蛋白拮抗蛋白；
背景信息：
In Xenopus, Gremlin 1 belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Gremlin 1(CKTFS1B1) is localized on human chromosome 15q13--> q15. Gremlin 1-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of Gremlin 1 is associated with tumor progression, and support the hypothesis that human Gremlin 1 may play an important role during both neuroembryological development and carcinogenesis.
